相文佩    医学博士，教授，博士生／硕士生导师。  

学术经历： 2005年毕业于www.365-818.com，获得妇产科学博士学位；2011年至2013年在美国匹兹堡大学医学中心做访问学者。  

社会兼职：中华医学会生殖医学分会青年委员，中华医学会计划生育分会青年 委员，湖北省医学会生殖医学分会委员，湖北省性学会理事。国家自然基金评审专家。  

学术成果：主持过国家自然科学基金项目2项；在国内外学术期刊发表论著四十余篇，其中SCI收录论文13篇。参编国家“十一五”规划教材《生殖疾病学》、《临床生殖医学》、《女性不育症》。  

 研究方向：  

1）卵巢早衰发病机制的研究；生殖衰老的表观遗传学及环境因素的研究。  

2）卵子发生研究：线粒体融合基因在卵子减数分裂过程中调控作用及机制研究。  

3）干细胞研究：成体干细胞在卵巢早衰及自然生殖衰老中的修复作用及机制探索。  

主持项目：  

1. 2016～2019：国家自然基金面上项目，BMSCs调控ERRα/Mfn2/ 线粒体途径改善老龄化卵泡发育和质量的探索性研究， (项目批准号：81571434)。  

2.  2013.1-2015.12，国家自然基金青年项目，线粒体融合蛋白Mfn2 调控线粒体功能对卵母细胞成熟和质量的影响， (项目批准号：31201079)。   

3. 主持省市级课题多项。  

代表论文和著作：(^#通讯作者，*第一或者并列第一作者)  

1. Liu Q, Kang L, Wang L, Zhang L, Xiang W^#. Mitofusin 2 regulates the oocytes development and quality by modulating meiosis and mitochondrial function. Sci Rep. 2016 Jul 29; 6:30561.   

2. Zhang L*, Xiang W*, Wang G, Yan Z, Zhu Z, Guo Z, Sengupta R, Chen AF, Loughran PA, Lu B, Wang Q, Billiar TR. Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein. J Biol Chem. 2016 Jul 15; 291(29): 15093-107.  

3. Wang L, Xu X, Kang L, Xiang W^#. Bone Marrow Mesenchymal Stem Cells Attenuate Mitochondria Damage Induced by Hypoxia in Mouse Trophoblasts. PLoS One. 2016 Apr 21; 11(4): e0153729.  

4. Chen W, Xu X, Wang L, Bai G, Xiang W^#. Low Expression of Mfn2 Is Associated with Mitochondrial Damage and Apoptosis of Ovarian Tissues in the Premature Ovarian Failure Model. PLoS One. 2015 Sep 1; 10(9): e0136421.  

5. Zhao N, Zhang Y, Liu Q, Xiang W^#. Mfn2 Affects Embryo Development via Mitochondrial Dysfunction and Apoptosis. Plos one. 2015 May 15; 10(5): e0125680.  

6. Pang WJ, Zhang Y, Zhao N, Darwiche SS, Fu XC, Xiang WP^#. Low expression of Mfn2 is associated with mitochondrial damage and apoptosis in the placental villi of early unexplained miscarriage. Placenta. 2013 Jul; 34(7): 613-8.  

7. Xu XY, Pang WJ, Wen ZN, Xiang WP^#. Changes in human umbilical vein   endothelial cells induced by endothelial nitric oxide synthase traffic inducer. J Huazhong Univ Sci Technolog Med Sci. 2013 Apr; 33(2): 272-6.  

8. Bhattacharjee R, Xiang WP*, Wang Y, Zhang X, Billiar TR. cAMP prevents TNF-induced apoptosis through inhibiting DISC complex formation in rat hepatocytes. Biochem Biophys Res Commun. 2012 Jun 22; 423(1): 85-90.  

9. Zhang Y, Jiang L, Hu W, Zheng Q, Xiang WP^#. Mitochondrial dysfunction during in vitro hepatocyte steatosis is reversed by omega-3 fatty acid-induced up-regulation of mitofusin 2. Metabolism. 2011, 60(6): 767-75.  

10.  Xiang WP*，Wen ZN，Pang WJ，Hu L,  Xiong CL,  Zhang Y. CR16 forms a complex with N-WASP in the human testes. Cell Tissue Res. 2011, 344(3): 519-26.  

11.  Chen QJ, Xiang WP^*, Zhang DK, Wang RP, Luo YF, Kang JZ, Cheng LN. Efficacy and safety of a levonorgestrel enteric-coated tablet as an over-the-counter drug for emergency contraception: a Phase IV clinical trial. Hum Reprod. 2011 Sep; 26(9): 2316-21.